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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

A Toll-like receptor recognizes bacterial DNA

Article Abstract:

Research into the Toll-like receptor family of mediators essential in microbial recognition is presented.

Author: Hemmi, Hiroaki, Takeuchi, Osamu, Kawai, Taro, Kaisho, Tsuneyasu, Sato, Shintaro, Sanjo, Hideki, Matsumoto, Makoto, Hoshino, Katsuaki, Wagner, Hermann, Takeda, Kiyoshi, Akira, Shizuo
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
DNA, Bacterial genetics, Microbiological chemistry

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I(kappa)B kinase-(alpha) is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

Article Abstract:

The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can recognize nucleic acids and trigger signaling cascades that activate plasmacytoid dendritic cells to produce interferon-alpha.

Author: Hemmi, Hiroaki, Kaisho, Tsuneyasu, Hoshino, Katsuaki, Akira, Shizuo, Ohara, Osamu, Tanaka, Takashi, Sugiyama, Takahiro, Matsumoto, Mitsuru, Saito, Masuyoshi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Cellular signal transduction, Interferon alpha, Dendritic cells

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Article Abstract:

The innate immune system senses viral infection by recognizing a variety of viral components, including double-stranded (ds)RNA, and triggers anti viral responses. The data obtained show that retinoic-acid-inducible protein I and melanoma-differentiation-associated gene 5 distinguish different RNA viruses and are critical for host antiviral responses.

Author: Takeuchi, Osamu, Kawai, Taro, Sato, Shintaro, Akira, Shizuo, Yamamoto, Masahiro, Matsuura, Yoshiharu, Uematsu, Satoshi, Fujita, Takashi, Yamaguchi, Osamu, Otsu, Kinya, Kato, Hiroki, Matsui, Kosuke, Jung, Andreas, Tsujimura, Tohru, Yoneyama, Mitsutoshi, Chang-Sung Koh, Ishii, Ken J., Sousa, Caetano Reis e
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Virus diseases, Proteins, Immune system, Tretinoin, Chemical properties

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Subjects list: Research, United States
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