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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Increased cell-to-cell variation in gene expression in ageing mouse heart

Article Abstract:

Increased transcriptional noise in aged tissue is tested by dissociating single cardiomyocytes from fresh heart samples of both young and old mice, followed by global mRNA amplification and quantification of mRNA levels in a panel of housekeeping and heart-specific genes. Results reveal that the heterogeneity of gene expression levels already prevalent among cardiomyocites from young heart was elevated at old age.

Author: Pollock, Brad H., Vijg, Jan, Bahar, Rumana, Hartmann, Claudia H., Rodriguez, Karl A., Denny, Ashley D., Busuttil, Rita A., Dolle, Martijn E.T., Calder, Brent R., Chisholm, Gary B., Klein, Christoph A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Messenger RNA, Gene amplification, Heart cells

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Article Abstract:

A study reveals a highly significant correlation between the liver transcriptome of old mice and a mouse model of progeroid syndrome. It is concluded that a known regulator of lifespan and it is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway.

Author: Vermeulen, Wim, Vijg, Jan, Niedernhofer, Laura J., Lalai, Astrid S., Garinis, George A., Raams, Anja, Robinson, Andria Rasile, Appeldoorn, Esther, Odijk, Hanny, Oostendorp, Roos, Ahmad, Anwaar, Leeuwen, Wibeke van, Theil, Arjan F., van der Horst, Meinecke, Peter, Kleijer, Wim J., Jaspers, Nicolaas G.J., Hoeijmakers Jan H.J., Gijsbertus T.J.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
DNA damage, Cell metabolism, Rodents as laboratory animals, Laboratory rodents

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Chromatin unbound

Article Abstract:

Sir2 proteins slow ageing in yeast by locking chromatin, the DNA and proteins in chromosomes into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.

Author: Vijg, Jan, Suh, Yousin
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Aging, Genetic aspects, Chromatin, Protein research, Aging (Biology)

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Subjects list: Research, United States
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