Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions

Article Abstract:

Rapid post-transcriptional changes in gene expression could be mediated by repositioning of translational components to sites of signal reception. These movements may be guided by mechanical tension. Research into whether cell binding to the extracellular matrix (ECM) encourages the formation of a cytoskeletal microcompartment specialized for translational control at the site of integrin binding indicates that mRNA and ribosomes localize to focal adhesion complexes that arise when cells bind to ECM-coated microbeads.

Cell interaction, Cell interactions

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Dynamics of individual flexible polymers in a shear flow

Article Abstract:

The real-time dynamics of individual, flexible polymers under a shear flow have been observed. Sheared polymers show several types of extended conformation, ranging from parallel to perpendicular. With shear rates smaller than the inverse of the relaxation time of the molecule, relative populations of the conformations are controlled by shear flow rate, questioning the assumptions of standard models of polymer dynamics.

Polymers, Shear flow

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Subcellular positioning of small molecules

Article Abstract:

Issues are presented concerning the partial treatment of cells using laminar flows to investigate the positioning of subcellular molecules. The movement of mitochondria in cytoskeletal structures is discussed.

Physiological aspects, Cells (Biology), Mitochondria, Cells, Laminar flow

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