Intercellular signalling in Drosophila segment formation reconstructed in vitro

Article Abstract:

Investigations of intercellular signalling in the embryonic development of Drosophila melanogaster were made in vitro. Segment polarity genes expressed as 'en' (engrailed) and 'wg' (wingless) suggests that the signalling process is involved in the patterning of segments. The 'wg' gene is proposed to maintain 'en' expression and the activation of other morphological and molecular processes as well. Signals from wg-expressing cells prevent the loss of en-expression at a critical period between three to five hours of egg-laying.

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Loss of gene function through rapid mitotic cycles in the Drosophila embryo

Article Abstract:

Analysis of rapid mitotic cycles in the Drosophila embryo show that these cycles constrain genetically-determined development during short 'phenocritical' periods by curtailing the length of genetic transcripts. The analysis concerned two Drosophila genes, knirps gene and knirps-related gene, which help determine abdomen segmentation. The necessary coordination of mitotic cycle duration and gene size probably works against rapid evolutionary change.

Mitosis

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Proximal - distal axis formation in the Drosophila leg

Article Abstract:

Genetic research shows that the Wingless and Decapentaplegic-dependent target genes in the leg of organism Drosophila direct the position of Proximal-Distal (P-D) axis development. The genes are required at specific areas along the P-D axis for gene expression. Leg patterns, through the expression of Dachshund and Distal-less proteins, are apparently determined by the expression of these genes.

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