Kainate receptors are involved in synaptic plasticity
Article Abstract:
It has been established that the kainate receptor involved in the induction of long-term potentiation may have at least one GluR5 subunit. However, this does not rule out roles for other kainate receptor subunits in synaptic plasticity. The kainate receptor-mediated element of excitatory synaptic transmission at mossy fibre synapses is both antagonized by GluR5 antagonists and absent in GluR6 knockout mice, and both subunits may therefore contribute to native kainate receptors in these neurons. It was not possible to establish whether mossy fibre long-term potentiation is induced pre- or postsynaptically.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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The synaptic activation of kainate receptors
Article Abstract:
Scientists have developed a method of activating kainate neurotransmitter receptors in CA3 neurons. The high-frequency stimulation of rat hippocampal mossy fibres with the selective AMPA receptor antagonist GYKI53655, and antagonists NMDA- and GABA-receptors, provides further evidence that kainate receptors act across the glutamatergic synapse.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Kainate receptors and synaptic plasticity
Article Abstract:
The kainate subtype of glutamate receptor is found to be essential for synaptic transmission plasticity in the brain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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