Knocking out memory's door
Article Abstract:
The role of long-term potentiation (LTP) of synaptic transmission in providing a neurological basis for memory has been confirmed by new genetic research. A.J. Silva and colleagues used gene targeting to produce mutant mice without the gene for the alpha-isoform of the calcium-calmodulin-dependent multifunctional protein kinase II that regulates LTP. These mutant mice were slower to learn new spatial tasks and exhibited less LTP than mice that had the gene. The research suggests that gene targeting has great promise as a means of studying the neurophysiology of memory.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Essential role of neocortical acetylcholine in spatial memory
Article Abstract:
An improvement in learning ability and renewal of memory is possible by introducing acetylcholine in the neocortex of rats with damage to the nucleus basalis magnocellularis. The function of acetylcholine is analyzed by installing acetylcholine-producing genetically modified cells in the denervated neocortical target regions of adult rats. The modified rats depict better spatial memory.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Repression revisited
Article Abstract:
Issues are presented concerning the development of an unambiguous model which can be used to determine the repression of memory in humans. The widespread and habitual repression of memory is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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