Kruppel-like factor 2 regulates thymocyte and T-cell migration

Article Abstract:

Kruppel-like factor 2 (KLF2) is shown to be essential for T-cell trafficking, besides regulating T-cell quiescence and survival. This is confirmed by the fact that KLF2-deficient thymocytes show impaired expression of several receptors required for thymocyte emigration and trafficking of peripheral T-cells including the sphingosine-1-phosphate (S1P) receptor S1[P.sub.1], critical for thymocyte egress and recirculation through peripheral lymphoid organs.

T cells, Cell migration

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Broken genes in solid tumours

Article Abstract:

Researchers have described the discovery of a gene associated with human non-small-cell lung cancer (NSCLC), which has accounted for about 80% of all lung cancer cases. Developing systematic genome-wide approaches for diagnosis by using gene fusions might help in understanding the causes of solid-tumour cancers.

United States, Analysis, Genetic aspects, Nucleotide sequence, Base sequence, Oncogenes, Tyrosine, Lung cancer, Non-small cell, Non-small cell lung cancer, Structure

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