Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Article Abstract:
Mutations in Drosphila scribble (scrib), which encodes a multi-PDZ and leucine-rich-repeat protein, create aberrant cell shapes and loss of the monolayer organization of embryonic epithelia. Investigation of the morphological and polarization phenotypes shown by scrib embryos indicates that Scrib is a vital element of epithelial architecture in the Drosophila ectoderm. It appears that its function is closely connected with that of the apical determinant Crumbs. The junctional protein Scrib specifically restricts apical membrane determinants to the apical cell surface.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Sending all the right signals
Article Abstract:
Wasserman and Freeman have shown how the development of an elaborate pattern during oogenesis is initiated by a simple instructive signal. They have documented the formation of respiratory appendages by activation of the epithelial growth factor receptor (EGFR) by Gurken (Grk), via signalling between oocyte and follicle cells. The paracrine signalling then initiates further signalling, and EGFR activity is amplified in an autocrine way.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Specificities of heparan sulphate proteoglycans in developmental processes
Article Abstract:
Developments in genetic studies are examined, with a focus on the complex and specific roles of heparan sulphate proteoglycans (HSPGs).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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