Long-distance long-term depression

Article Abstract:

It has been possible to use simultaneous recordings from three interconnected neurons in culture to prove that long-term potentiation (LTP) is not restricted to the synapses at which it is induced. Instead, it extends to other synapses in the microcircuit. It is likely that this spreading out takes place through synapses moving retrogradely across the synapse. This research may also shed valuable light on how far long-term depression spreads.

Neurobiology

---

Presynaptic changes during mossy fibre LTP revealed by NMDA receptor-mediated synaptic responses

Article Abstract:

Many N-methyl-D-aspartate (NMDA) receptor sites capable of expressing a NMDA receptor-dependent form of long-term potentiation (LTP) were revealed at excitatory synapses in anatomical studies of the CA1 region of the hippocampus. The results of the studies indicate that mossy fiber synapses activate only alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and show a NMDA-independent LPT form.

---

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

Article Abstract:

The exocytosis of glutamate in nerve terminals of the cerebrocortex is mediated by the presence of a metabotropic glutamate receptor in the presynaptic region. This potentiation occurs only when archidonic acid is present, which may act as a retrograde messenger. If this is the case, then the presynaptic release of glutamate may occur only in concert with the postsynaptic generation of arachidonic acid.

Physiological aspects, Glutamate, Exocytosis

Similar abstracts:

• Abstracts: Consequences of different suckling systems for reproductive activity and productivity of cattle in tropical conditions
• Abstracts: Mapping the conformational wave of acetylcholine receptor channel gating. Reaction mechanism determines NMDA receptor response to repetitive stimulation
• Abstracts: The mouse map gets a lot more signposts. The shape of protein structures to come. To catch a wave
• Abstracts: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
• Abstracts: Cloning and expression of a rat brain L-glutamate transporter. Intimate contact enables transport

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.