The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

Article Abstract:

The functionally conserved proteins p300 and CPB have fundamental acetylase activity and act, with other factors, to activate transcription of DNA. A new SRC family member, p/CIP, has been discovered which is a significant component of the CBP/p300 cell. Research shows that full ligand-activated gene transcription in the examined cells requires the presence of both NCoA-1 and the CBP/p/CIP complex.

DNA, Molecular biology, Ligand binding (Biochemistry)

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

Article Abstract:

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is an important transcription factor in adipocyte differentiation and glucose homeostasis. The x-ray crystal structure of the human apo-PPAR-gamma ligand-binding domain (LBD) is presented, revealing a large binding pocket. The ternary complex containing the PPAR-gamma LBD is described, along with 88 amino acids of human SRC-1.

Peroxisomes

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