Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

Article Abstract:

The action spectrum for phase-shifting the circadian rhythm of locomotion in mice lacking rods and cones matches with the pupillary light reflex and with the intrinsic photosensitivity of the melanopsin-expressing retinal ganglion cells. Furthermore, mice lacking melanopsin and with nonfunctional rod and cone phototransduction mechanism exhibit intact retina without pupil reflex. Together, the results suggest that rod-cone and melanopsin systems are essential for all visual functions.

United Kingdom, Canada, Germany, Physiological aspects, Mice, Mice (Rodents), Vision, Properties, Brain stimulation

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Retinal repair by transplantation of photoreceptor precursors

Article Abstract:

A study shows that donor cells can integrate into the adult or degenerating retina if they are taken from the developing retina at a time coincident with the peak of rod genesis, where these transplanted cells integrate, differentiate into rod photoreceptors, form synaptic connections and improve visual function. The analysis has defined the ontogenetic stage of donor cells for successful rod photoreceptor transplantation.

Health aspects, Antigen receptors, T cell, T cell antigen receptors, Retina, Cells, T cells, Cell transplantation

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Addition of human melanopsin renders mammalian cells photoresponsive

Article Abstract:

A few of the mammalian retinal ganglion cells serve as photoreceptors for formulating specific photo responses that do not form any image. The melanopsin photoresponse depends on the existence of cis isoforms of retinaldehyde and is specifically susceptible to light that has a short wave length.

Genetic aspects, Mammals

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