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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

MicroRNA silencing through RISC recruitment of elF6

Article Abstract:

The study results related to the human RISC (RNA-induced silencing complex) associates with a multiprotein complex containing MOV10 which uncovers an evolutionarily conserved function of the ribosome anti-association factor elF6 in miRNA-mediated post-transcriptional silencing is presented.

Author: Pasquinelli, Amy E., Shiekhattar, Ramin, Gregory, Richard I., Baillat, David, Chendrimada, Thimmaiah P., Finn, Kenneth J., Xinjun Ji, Liebhaber, Stephen A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Ribosomes, Structure, Gene silencing

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CRD-BP mediates stabilization of [beta]TrCP1 and c-myc mRNA in response to [beta]-catenin signalling

Article Abstract:

CRD-BP mediates stabilization of [beta]TrCP1 and c-myc mRNA in response to [beta]-catenin signaling. CRD-BP induction in the upregulation of [beta]TrCP1, in the activation of dimeric transcription factor and in the suppression of apoptosis is implicated in the suppression of cancers.

Author: Fuchs, Serge Y., Minamoto, Toshinari, Noubissi, Felicite K., Elcheva, Irina, Bhatia, Neehar, Shakoori, Abbas, Ougolkov, Andrei, Jianghuai Liu, Ross, Jeff, Spiegelman, Vladimir S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Health aspects, Apoptosis

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The microprocessor complex mediates the genesis of microRNAs

Article Abstract:

It is shown that human Drosha is a component of two multi-protein complexes. The larger complex contains multiple classes of RNA-associated proteins including RNA helicases, and the smaller complex is composed of Drosha and the double-stranded-RNA-binding protein, DGCR8.

Author: Gregory, Richard I., Kai-ping Yan, Amuthan, Govindasamy, Chendrimada, Thimmaiah, Doratotaj, Behzad
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004

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Subjects list: Research, United States, Analysis, Gene expression, Messenger RNA, Binding proteins
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