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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

Article Abstract:

Results demonstrate that intramembrane proteolysis by the intramembrane serine proteases, rhomboid proteins, regulates cellular processes besides signalling. Data indicate that cleavage of the dynamin-like GTPase regulates mitochondrial membrane remodelling in Saccharomyces cerevisiae. The dynamin-like GTPase is one of the two substrates of RBD1 rhomboid protein, which is an inner membrane protein.

Author: Freeman, Matthew, McQuibban, G. Angus, Saurya, Saroj
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Cellular control mechanisms, Cell regulation, Proteolysis, Mitochondrial membranes, Mitochondrial membrane

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Feedback control of intercellular signalling in development

Article Abstract:

The fate of cells in animal development depends on precisely-controlled intercellular communication. Research reveals that this form of signalling is regulated to a significant extent by positive and negative feedback loops that give signals information about versatility, precision, and robustness.

Author: Freeman, Matthew
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Cells (Biology), Growth, Communication in science, Scientific communication, Cells, Cell research, Cytological research

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Enzyme theory holds water

Article Abstract:

The first high-resolution structure of an intramembrane protease is presented. The rhomboid family is proposed to be serine-type intramembrane proteases and the rhomboid structure gives the first detailed view of intramembrane proteins, correlating with earlier genetic and biomedical studies.

Author: Freeman, Matthew
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Science & research, Genetic aspects, Enzymes, Membrane proteins, Enzyme structure-activity relationships, Structure

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Subjects list: United Kingdom, Physiological aspects, Proteases, Research
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