Na+ channel subunits and Ig domains

Article Abstract:

Voltage-gated sodium channels situated within brain cells consist of a central pore-forming alpha-subunit and two auxiliary subunits, namely beta1 (B1) and beta2 (B2). The a-subunit is a polytopic transmembrane glycoprotein while B1 and B2 are single membrane-spanning glycoproteins. The extracellular domains of B1 and B2 contain immunoglobulin-like motifs which have three structural sets. In addition, their basic residues contain a critical tryptophan. Structural comparisons of the two subunits support the hypothesis that their immunoglobulin-like motifs act as neural cell-adhesion molecules that interact with extracellular molecules.

Physiological aspects, Brain, Sodium channels, Immunoglobulin genes

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Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

Article Abstract:

A study was conducted on a cytoplasmic loop linking domains II and III where syntaxin binds to N-type Ca2+ channels reacts independently with syntaxin and SNAP25, which has a biphasic dependence on Ca2+. Syntaxin, SNAP25 and the synaptic core complex were found to interact with the N-type Ca2+ channel through LII-III, suggesting that synaptic vessels attach to presynaptic Ca2+ channels through the interaction. The interaction is dependent on changes in Ca2+ when initiation of transmitter release is at the threshold.

Calcium channels, Neurotransmitters, Cytoplasm

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Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP

Article Abstract:

An attempt is made to identify a molecular basis for inter-population variation in paralytic shellfish poisoning (PSP) resistance within a species, consistent with genetic adaptation to PSP toxins (PSTs). The results show that PSTs can act as potent natural selection agents, leading to greater toxin resistance in clam populations and increased risk of PSP in humans.

United States, Science & research, Shellfish, Shellfish Fishing, Genetic aspects, Microbial toxins, Saxitoxin

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