Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene

Article Abstract:

Ataxia is displayed in heterozygous Lurcher mice due to selective, cell-autonomous and apoptic cerebellar Purkinje cell death during postnatal development. The mutations responsible for neurodegeneration in lurcher mouse alleles have been identified, through posititional cloning, as G-to-A transitions. This changes alanine to a threonine residue in the transmembrane domain III of the mouse delta2 glutamate receptor gene, indicating that apoptotic neuronal death in Lurcher mice could provide a model for excitotoxic cell death.

Cell death, Cell receptors

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Survival by self-digestion

Article Abstract:

Mammals face problem just after birth, as they are no longer nourished through the placenta. The death of Atg-5-knock-out mice after birth support the hypothesis that autophagy is essential for survival during the unique period experienced by mammals as they make the transition form transplacental nutrition to milk.

Behavior, Food and nutrition, Mammals, Wilderness survival

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One-hit neuronal death

Article Abstract:

Issues are presented concerning research into the genes whose mutation results in neurodegenerative illnesses such as Parkinson's disease, Alzheimer's disease or amyotrophic lateral sclerosis.

Nervous system, Nerve degeneration, Nervous system diseases

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