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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Opioids block long-term potentiation of inhibitory synapses

Article Abstract:

A report on long-term potentiation of [GABA.sub.A] (gamma-amino-butyric acid)-mediated synaptic transmission onto dopamine neurons of the rat brain ventral segmental area, a region required for the development of drug addiction is presented. It is observed that the neuroadaptations to opioid drugs contributes to the early stages of addiction and this can be exploited therapeutically using drugs targeting [GABA.sub.A] receptors.

Author: Nugent, Fereshteh S., Penick, Esther C., Kauer, Julie, A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Brain research, Dopamine

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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

Article Abstract:

Oleylethanolamide (OEA), a naturally occurring lipid regulating satiety and body weight, binds with high affinity to the peroxisome-proliferator-activated receptor-alpha (PPAR-alpha), a nuclear receptor that regulates several aspects of lipid metabolism. The results identify an unexpected role for this nuclear receptor in regulating behavior and raise possibilities for the treatment of eating disorder.

Author: Piomelli, Daniele, Jin Fu, Tarzia, Giorgio, Gaetani, Silavana, Oveisi, Fariba, Verme, Jesse Lo, Serrano, Antonia, Fonseca, Fernando Rodriguez de, Rosengarth, Anja, Luecke, Hartmut, Giacomo, Barbara Di
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Care and treatment, Eating disorders, Lipid research, Receptor antibodies

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An endocannabinoid mechanism for stress-induced analgesia

Article Abstract:

A demonstration that an opioid-independent form of stress-induced analgesia is mediated by the release of endogenous marijuana-like compounds in the brain is presented. The results indicate that the coordinated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independent stress-induced analgesia.

Author: Walker, Michael, Fegley, Darren, Duranti, Andrea, Tontini, Andrea, Mor, Marco, Tarzia, Giorgio, Hohmann, Andrea G., Crystal Jonathan D., Supita, Richard L., Holmes, Philip V., Bolton, Nathan M., Neely, Mark H., Krey, Jocelyn F., Mangieri, Regina, Piomelli, Daniel
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Usage, Drug therapy, Cannabinoids, Analgesia

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Subjects list: Research, Opioids, United States
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