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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

Article Abstract:

The promyelocytic leukaemia (PML) is identified as a critical inhibitor of neoangiogenesis in vivo, in both ischaemic and neoplastic conditions, through the control of protein translation. It is shown that in hypoxic conditions PML acts as a negative regulator of the synthesis rate of hypoxia-inducible factor 1alpha (HIF-1alpha) by repressing mammalian target of rapamycin (mTOR) and hence PML is found to be a novel suppressor of mTOR and neoangiogenesis.

Author: Pandolfi, Pier Paolo, Simon, M. Celeste, Cordon-Cardo, Carlos, Rafii, Shahin, Bernardi, Rosa, Teruya-Feldstein, Julie, Guernah, Ilhem, Grisendi, Silvia, Alimonti, Andrea, Jin, David
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Pennsylvania, Health aspects, Diagnosis, Neovascularization, Rapamycin, Acute leukemia, Rats as laboratory animals, Laboratory rats

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Role of nucleophosmin in embryonic development and tumorigenesis

Article Abstract:

The role of nucleophosmin also known as NPM, B23, NO38 in embryonic development and tumorigenesis is studied. Experts report that NPM is haploinsufficient in the control of genetic stability and that NPM1 heterozygosity accelerates oncogensis in both in vitro and in vivo.

Author: Pandolfi, Pier Paolo, Manova, Katia, Bernardi, Rosa, Grisendi, Silvia, Rossi, Marco, Ke Chang, Khandker, Lupia
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Embryology, Carcinogenesis, Heterozygosis, Heterozygote

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