Pax3 functions at a nodal point in melanocyte stem cell differentiation
Article Abstract:
The molecular details of a nodal point in adult melanocyte stem cell differentiation is described in which Pax3 simultaneously functions to initiate a melanogenic cascade while acting downstream to prevent terminal differentiation. A stem cell transcription factor can determine cell fate as well as simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Postnatal isL1 (super) + cardioblasts enter fully differentiated cardiomyocyte lineages
Article Abstract:
The identification of isl1(super)+ cardiac progenitors in postnatal rat, mouse and human myocardium is reported. The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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An eye on organ development
Article Abstract:
The identification of the single gene which could induce the formation of an entire organ or tissue was the most remarkable discovery of the past decade. The relationship between the catalytic and biological activities of Eyes absent (Eya) is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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