Perinuclear localization of chromatin facilitates transcriptional silencing

Article Abstract:

It is possible to silence an HMR locus with a defective silencer by anchoring the locus to the nuclear periphery. This silencing needed the hybrids of the GAL4 DNA-binding domain with membrane proteins, the GAL4-binding sites and the silent information regulator proteins. It seems that a membrane protein, when fused to GAL4 DNA-binding domains and overexpressed, is able to bind to GAL4-binding sites on the chromosome and recruit nearby genes to the nuclear periphery. It is uncertain why such localization facilitates silencing.

Research, DNA binding proteins

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Cyclin encoded by KS herpesvirus

Article Abstract:

Kaposi's sarcoma associated herpesvirus (KSHV) is a gamma-herpesvirus with an open reading frame (ORF 72) whose sequence is similar to cellular cyclins, especially the D-type cyclins. Inappropriate activation of kinases occurs in the presence of ectopic expression of KSHV-cyclin protein in latently infected host cells. The kinase activation usually requires cellular cyclins. KSHV-cyclin prevents cell cycle arrest in SAOS2 cells. This may reveal the role of virus in tumor development.

Reports, Physiological aspects, Proteins, Kaposi's sarcoma

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