Pirated genes in Kaposi's sarcoma
Article Abstract:
A virally encoded chemokine receptor is proposed to function as an oncogene in malignancies that occur frequently in AIDS patients, such as Kaposi's sarcoma and primary effusion lymphoma. Kaposi's sarcoma-associated herpesvirus (KSHV) GPCR activates a certain G protein in the absence of chemokine ligands, which, in turn, activates a mitogenic signalling pathway involving phosphoinositide-specific phospholipase C. The KSHV G-protein-coupled receptor is shown to be a genuine signalling receptor with a constitutive activity in the phosphoinositide pathway in COS-1 cells. It also triggers cellular proliferation, making it a potential viral oncogene.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint
Article Abstract:
HOX11 is an orphan homeobox gene and also an oncogene. Evidence is presented showing the protein HOX11 interacting with protein serine-threonine phosphatase 2A catalytic (PP2A) subunit and protein phosphatase 1 (PP1) in mammalian cells. Research findings indicate that HOX11 is a cellular oncogenic similar to oncogenic viruses and chemical tumor promoters in that it also goes after PP2A and PP1. The interaction between HOX11 and PP2A and PP1 suggests the existence of a means enabling a homeobox gene to disrupt the cell cycle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Zen and the art of Fos and Jun
Article Abstract:
The X-ray crystal structure of the Jun and Fos oncogenes bound to DNA as a dimer has been determined by Harrison and Glover. The crystal structure reveals that the subunits of these genes have continuous alpha-helices. The oncogenes were isolated as retroviral transforming genes individually in the Finkel-Biskis-Jinkins murine osteogenic sarcoma virus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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