Potent antitumour activity of a new class of tumour-specific killer cells
Article Abstract:
Tumor-specific cytotoxic lymphocytes can be produced by genetic modification to produce and secrete a targeted toxin against an oncoprotein on tumor cell surfaces. The production and accumulation of targeted toxins inside tumors by migrated lymphocytes is more effective than direct immunotoxin administration. Micrometastases can be selectively destroyed by reinfused transduced lymphocytes due to its immune surveillance function. Any antigen on the cell surface can be targeted making this approach applicable to treatment of cancer, autoimmune diseases and virus infection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A vancomycin surprise
Article Abstract:
Novak and colleagues studied clinical streptococcus pneumoniae isolates and found that around 3% were tolerant to antibiotics. They found that multiple-antibiotic-tolerant pneumococci can selectively persists in experimental meningitis. Such mutants were more able to take up DNA than normal cells. The genetic basis for vancomycin tolerance was traced to the specific mutation of a two-component signal-transduction system.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Article Abstract:
Cancer research shows that the therapeutic effects of anti-angiogenic drug Endostatin are not limited by acquired drug resistance. Experiments using mice with cancers Lewis Lung carcinoma, T241 fibrosarcoma and B16F10 melanoma demonstrate that consistent treatment-discontinuation cycles are increasingly effective with repetition. Cycled endostatin therapy results are given.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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