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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Proportionally more deleterious genetic variation in European than in African populations

Article Abstract:

Several studies and tests are conducted to estimate the number of functionally consequential single-nucleotide polymorphisms (SNPs) that are carried by the African America (AA) and European American (EA) individuals. The EA individuals are found to exhibit higher number of deleterious genetic variation, as compared to that of the AA population.

Author: Clark, Andrew G., Nielsen, Rasmus, Sninsky, John J., White, Thomas J., Bustamante, Carlos D., Hernandez, Ryan D., Sunyaev, Shamil R., Schmidt, Steffen, Lohmueller, Kirk E., Indap, Amit R., Boyko, Adam R., Hubisz, Melissa J.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
Genetic variation

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Genotype, haplotype and copy-number variation in worldwide human populations

Article Abstract:

The article presents a complete analysis of the variations in the high-quality genotypes, haplotype and copy-number in worldwide human populations. The results obtained helps in understanding the history of migration, range expansion and adaptation of the human species in different parts of the world.

Author: Hardy, John A., Kai Wang, Bucan, Maja, Jakobsson, Mattias, Scholz, Sonja W., Scheet, Paul, Gibbs, J. Raphael, VanLiere, Jenna M., Hon-Chung Fung, Szpiech, Zachary A., Degnan, James H., Guerreiro, Rita, Bras, Jose M., Schymick, Jennifer C., Hernandez, Dena G., Traynor, Bryan J., Simon-Sanchez, Javier, Matarin, Mar, Britton, Angela, van de Leemput, Joyce, Rafferty, Ian, Cann, Howard M., Rosenberg, Noah A., Singleton, Andrew B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008

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Variants conferring risk of atrial fibrillation on chromosome 4q25

Article Abstract:

The study helps in the identification of various variants that causes atrial fibrillation (AF), the most common sustained cardiac arrhythmia in humans. Two variants on chromosome 4a25 are found to be increase the risk of AF to a large extent, as they are adjacent to PITX2.

Author: Rosand, Jonathan, Furie, Karen L., Greenberg, Steven M., Stefansson, Kari, Kelly, Peter, Kong, Augustine, Gulcher, Jeffrey R., Ellinor, Patrick T., Sigurdsson, Asgeir, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Kristjansson, Kristleifur, Helgadottir, Anna, MacRae, Calum A., Arnar, Daniel O., Gretarsdottir, Solveig, Holm, Hilma, Jonasdottir, Adalbjorg, Baker, Adam, Thorleifsson, Gudmar, Palsson, Arnar, Blondal, Thorarinn, Sulem, Patrick, Backman, Valgerdur M., Hardarson, Gudmundur A., Palasdottir, Ebba, Helgason, Agnar, Sigurjonsdottir, Runa, Sverrisson, Jon T., Kostulas, Konstantinos, Ng, Maggie C.Y., Baum, Larry, Wing Yee So, Ka Sing Wong, Juliana C.N. Chan, Ma, Ronald C.W., Sale, Michelle, Smith, Eric E., Hillert, Jan, Thorgerisson, Gudmundur
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United States, Health aspects, Causes of, Atrial fibrillation, Human chromosomes

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Subjects list: Research, Population genetics, Single nucleotide polymorphisms, Haplotypes
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