Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

Article Abstract:

Prototypes of the heparin-binding fibroblast growth factor (FGF) family, acidic FGF (FGF-1) and basic FGF (FGF-2) promote endothelial cell growth and angiogenesis in vascular cells. A eukaryotic expression vector encoding a secreted form of FGF-1 was introduced into porcine arteries to determine its role in in vivo vascular pathology. Intimal hyperplasia of porcine arteries and angiogenesis was observed after FGF-1 was introduced. It is suggested that blood flow to ischaemic tissues can be enhanced through a gene transfer of FGF-1.

Physiological aspects, Neovascularization, Arteries, Vascular endothelium, Hyperplasia

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A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

Article Abstract:

It is necessary to find a vaccine that can avert the chances of a reoccurrence of the severe acute respiratory syndrome disease. The study conducted reveals a DNA vaccine, that encodes the spike glycoprotein of the SARS-severe acute respiratory syndrome diseaseCoV, induces T cell and neutralizes antibody responses.

Science & research, DNA vaccines, Severe acute respiratory syndrome

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Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates

Article Abstract:

The development of accelerated vaccination against Ebola virus in non-human primates is described. The antibody response to immunization with an adenoviral vector encoding the Ebola glycoprotein is induced more rapidly than with DNA priming and ADV boosting.

United States, Product development, Vaccines, Ebola virus

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