Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

Article Abstract:

Rb-deficient embryos carry profound abnormalities of fetal liver macrophages that prevent physical interactions with erythroblasts but in contrast, wild-type macrophages bind Rb-deficient erythroblasts and lead them to terminal differentiation and enucleation. Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythopoiesis.

Human embryo, Human cell culture

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Degradation of ld2 by the anaphase-promoting complex couples cell cycle exit and axonal growth

Article Abstract:

Id2, inhibitor of DNA- binding 2, is shown to interact with the core subunits of APC/C and Cdh1 in primary neurons. AC/[C.sup.Cdh1] initiates a chain of events by setting the timing of Id protein degradation in the nervous system, which terminates with the activation of downstream targets of bHLH transcription factors.

Massachusetts, Health aspects, Analysis, Genetic aspects, Biodegradation, DNA binding proteins, Cell proliferation, DNA-ligand interactions, DNA binding, Axonal transport

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

Article Abstract:

Research is presented concerning the influence of Id proteins in the coordination of cell differentiation and proliferation in mice. The dominant-negative antagonist features of Id2 are discussed.

Physiological aspects, Proteins, Tumor suppressor genes, Retinoblastoma, Oncology

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