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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

Article Abstract:

It has been possible to identify two residues of Nijmegen breakage syndrome (NBS)-1, Ser 278 and Ser 343, that are phosphorylated in vitro by ATM, the protein product of the gene responsible for ataxia-telangiectasia. The modification in vivo of these residues is vital for the cellular response to DNA damage.

Author: Shay, Jerry W., Zhao, Song, Weng, Yi-Chinn, Yuan, Shyng-Shiou F., Lin, Yi-Tzu, Hsu, Hao-Chi, Lin, Suh-Chin J., Gerbino, Elvira, Song, Mei-hua, Zdzienicka, Malgorzata Z., Gatti, Richard A., Ziv, Yael, Shiloh, Yosef, Lee, Eva Y.-H. P.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Article Abstract:

Research into Nijmegen breakage syndrome is presented. It has been established that Nbs is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. Phosphorylation of Nbs by the ataxia telangiectasia mutated gene is vital for certain responses of human cells to DNA damage.

Author: Livingston, David M., Lane, William S., Wu, Xiaohua, Ranganathan, Velvizhi, Weisman, David S., Heine, Walter F., Ciccone, David N., O'Neill, Ted B., Crick, Kindra E., Pierce, Kerry A., Rathbun, Gary, Weaver, David T.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000

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Crossing over to drug resistance

Article Abstract:

The chemotherapeutic drug resistance mechanism and the action of drugs that are used for the treatment of breast and ovarian cancers are investigated. The drug resistance is found to develop on the restoration of homologous recombination (HR), a DNA-damage repair pathway.

Author: Livingston, David M., Silver, Daniel P.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Anticancer Drugs, Chemotherapeutic Drugs, Care and treatment, Breast cancer, DNA repair, Antineoplastic agents, Antimitotic agents

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Subjects list: Research, Genetic aspects, DNA damage, Genetic disorders, Ataxia telangiectasia
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