Reduction of atherosclerosis in mice by inhibition of CD40 signalling
Article Abstract:
The hypothesis that the development of atherosclerosis in mice could be mitigated by the administration of a neutralizing anti-CD40L monoclonal antibody, has been tested. The results provide evidence for a significant regulatory role for CD40 signalling in atherogenesis in mice with higher low-density lipoprotein levels. When CD40L-CD40 signalling was blocked, there was a marked decrease in atherosclerotic plaque formation, and arterial lipid deposition, as well as lesional expression of the VCAM-1 molecule, considered to be important in atherogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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The nuclear receptor LXR is a glucose sensor
Article Abstract:
A study shows how glucose binds and stimulates the transcriptional activity of the liver X receptor (LXR), a nuclear receptor that coordinates hepatic lipid metabolism. LXR senses surplus glucose, induces fatty acid synthesis and prompts hepatic export of very low-density lipoprotein and with its ability to bind both glucose and oxysterols it could be the link between hyperglycemia and atherosclerosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
Article Abstract:
An investigation on the effects of delta-9-tetrahydrocannabinol (THC) in a murine model of established atherosclerosis is presented. The data obtained demonstrated that oral treatment with a low dose of THC inhibits atherosclerosis progression in the apliproprotein E knockout mouse model, through pleiotropic immunomodulatory effects on lymphoid and myeloid cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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