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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Regulation of an extrathymic T-cell development pathway by oncostatin M

Article Abstract:

The expression of an oncostatin M transgene in the early T cell lineage stimulates the accumulation of mature and immature T cells in lymph nodes. This thymus-independent pathway of T-cell development helps in T-cell immunodeficiency. The administration of oncostatin M protein stimulates a 500-fold increase in Thy-1+ lymph node cells, and restores immune responsiveness in transgenic and non-transgenic mice.

Author: Clegg, Christopher H., Rulffes, Jeffrey T., Wallace, Philip M., Haugen, Harald S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
Physiological aspects, Observations, Gene expression, T cells, Mice as laboratory animals, House mouse, Immunodeficiency

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

Article Abstract:

A new study identifies two receptors for the tumour necrosis factor zTnF4 and establishes a link between zTNF4 and autoimmune disease. TaCI-Ig is identified as a possible treatment for human autoimmune disease.

Author: Gross, Jane A., Johnston, Janet, Mudri, Sherri, Enselman, Rachel, Dillon, Stacey R., Madden, Karen, Xu, Wenfeng, Parrish-Novak, Julia, Foster, Donald W., Lofton-Day, Cathy, Moore, Margaret, Littau, Alisa, Grossman, Angelika, Haugen, Harald, Foley, Kevin, Blumberg, Hal, Harrison, Kim, Kindsvogel, Wayne, Clegg, Christopher H.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Autoimmune diseases, B cells

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Interleukin 21 and its receptor are involved in NK cell expansionand regulation of lymphocyte function

Article Abstract:

A class 1 cytokene receptor is identified and described in detail, with its probable role explained.

Author: Parrish-Novak, Julia, Dillon, Stacey et al
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Interleukins, Cellular control mechanisms, Cell regulation

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