Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

Article Abstract:

Kainate autoreceptors regulate the release of glutamate without the mediation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. Kainate suppresses the release of L-glutamate from rat hippocampal synaptosomes and reduces glutamatergic synaptic transmission. Kainate antagonists reverse the suppression, but AMPA antagonists are unable to do so. The inhibitory action of kainate on the release of amino acids is through its action on kainate autoreceptors, and not via AMPA receptors.

Glutamate

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A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

Article Abstract:

L-glutamate is the main excitatory neurotransmitter in the central nervous system of vertebrates that acts on three classes of ionotripic glutamate receptors: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, N-methyl-D-aspartate and kainate. However, the role of kainate receptors is ill understood. A new study shows that kainate receptors regulate synaptic inhibition in the hippocampus and could contribute to kainate's epileptogenic effects.

Hippocampus (Brain), Synapses

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Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Article Abstract:

(RS)-alpha-methyl-4-carboxy phenylglycine is used to examine the nature of the involvement of mGluRs in long-term potentiation (LTP). It is a specific mGluR antagonist in the Lippocampus. Synaptic activation of mGluRs is necessary for the induction of both NMDA receptor-dependent and NMDA receptor-independent forms of LTP in the Lippocampus.

Analysis, Methyl aspartate, N-methyl-D-aspartate

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