Relationship between asymmetric nodal expression and the direction of embryonic turning

Article Abstract:

The sideness of nodal expression in inv mutant embryos is associated with the direction of embryonic turning and heart looping. A nodal-lacZ reporter allele is used to describe asymmetric nodal expression in mouse node. Nodal is asymmetrically expressed in the ventral-lateral cells of mature nodes and in the subpopulation of mesodermal cells during the late-streak-early-somite stage embryos. Nodal-lacZ expression in lateral mesoderm is restricted to the right-hand side of the embryo. The genetic pathways responsible for the left-right body axis in mammals are conserved in vertebrates.

Gene expression, Symmetry (Biology)

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Nodal signalling in the epiblast patterns the early mouse embryo

Article Abstract:

It has been established that Nodal signals from the epiblast are responsible for the initiation of proximal-distal polarity in the early mouse embryo. Extremely dynamic patterns of Nodal expression in the early embryo were found to be controlled by the interplay of two clear cis-regulatory regions.

Polarity (Biology), Animal anatomy

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An LDL-receptor-related protein mediates Wnt signalling in mice

Article Abstract:

New evidence shows that a previously unknown member of the low-density lipoprotein-receptor-related protein family, LRP6, is essential for Wnt signalling in mice.

Gene mutations, Gene mutation, Low density lipoproteins, Embryology, Animal embryology

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