Restricted maximum likelihood estimation of additive genetic variance when selected base animals are considered fixed

Article Abstract:

A simulation study of a base generation of assumed unrelated and unselected 20 sires and 20 dams was indiscriminately mated to produce 200 malesand 200 females, then phenotypically 20 best males were selected and each matedwith 20 females in each of 5 subsequent generations. Only 4th and 5th generations with performance records and pedigree information were included in the study. It was concluded that estimates in a model with base animals assumedas fixed were not biased by selection but a new bias was introduced if progeny of fixed base animals were selected.

Genetic aspects, Genetic research, Animal breeding

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Estimation of direct and correlated responses to selection using univariate animal models

Article Abstract:

Analysis with simple models showed that the estimates of selection response of univariate experiments could be completely dependent on the prior heritability parameter, or both on the prior and on the true heritability parameter under certain conditions. Computer simulations supported the results of the analysis of simple models. The results indicate erroneous results could be obtained when univariate animal models are used to estimate selection response in breeding programs in which the breeding objectives involve correlated traits.

Breeding

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Factors that affect drug disposition in food-producing animals during maturation

Article Abstract:

The factors that affect drug disposition in food-producing animals during maturation were evaluated. It was shown that developmental changes play an important role in drug metabolism since drug biotransformation and excretion are dependent on the capacity of the liver and the kidneys to handle drugs. It is therefore imperative that drug pharmacokinetics be studied for each specific drug to avoid overloading the immature organs.

Research, Evaluation, Physiological aspects, Kidneys, Drug use, Animals, Kidney, Drug metabolism, Pharmacokinetics, Veterinary pharmacology

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