Role of CED-4 in the activation of CED-3

Article Abstract:

It has been found through genetic analyses of the nematode Caenorhabditis elegans, that CED-3 and CED-4 promote cell death, whereas CED-9 inhibits cell death. Little is known about the function of CED-4, although studies show that it could interact independently with CED-3 and CED-9. A test to determine whether CED-4 could bind ATP, used ATP analogues labelling protein nucleotide-binding sites. It was found that CED-4 has an intrinsic enzymatic activity facilitating CED-3 auto-activation, and is central to the molecular regulation of cell-death.

Drugs, Cellular Protein, In-Vitro Diagnostic Substance Manufacturing, Physiological aspects, Cellular proteins, Nematoda, Nematodes

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort 1

Article Abstract:

Apoptosis research has established that newborn mice with FADD+ embryonic stem cells and FADD+ chimeras have the same thymocyte subpopulations as normal mice. Timed experiments show that the thermocyte subpopulations decrease over time while peripheral T cells do not. The presence of cytokine interleukin-2 does not prevent the impairment of activation-induced cell proliferation. Evidence indicates that apoptosis may be linked to cell proliferation.

Cell proliferation

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

Article Abstract:

Research is presented concerning the stimulation of the T-cell receptor (TCR) on cycling peripheral T cells in order to activate a process named TCR-activation-induced cell death.

T cell antigen receptors, T cells, Letter to the Editor

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