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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

Article Abstract:

Mice with a disruption in the NF-ATc gene do not develop normal cardiac valves and septa and die of circulatory failure. It is suggested that the Ca(super2+)/calcineurin/NF-ATc signalling pathway is critical for normal cardiac valve and septum morphogenesis. NF-ATc and its regulatory pathways may be candidates for genetic defects underlying congenital human heart disease.

Author: Wakeham, Andrew, Potter, Julia, Mak, Tak W., Yoshida, Hiroki, Crabtree, Gerald R., Timmerman, Luika A., Samper, Enrique, de la Pompa, Jose Luis, Takimoto, Hioaki, Elia, Andre J., Marengere, Luc, Lowell Langille, B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Research, Genetic transcription, Transcription (Genetics), Morphogenesis, Heart valves

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T-cell co-stimulation through B7RP-1 and ICOS

Article Abstract:

It has been possible to establish the human protein ICOS and the ligand B7-related protein-1 (B7RP-1) as a receptor-ligand pair able to undertake extensive co-stimulatory activity in vitro and in vivo. This pair has structural links with CD28-B7 and participates in the adaptive immune response. It was found that the interaction between ICOS and B7RP-1 is specific and separate from that taking place between CD28 and B7.

Author: Zhang, Ming, Mak, Tak W., Scully, Sheila, Shahinian, Arda, Duncan, Gordon, Horan, Tom, Whoriskey, John S., Khare, Sanjay D., Chang, David, Brankow, David, Van, Gwyneth, Yoshinaga, Steven K., Sarmiento, Ulla, Guo, Jane, Shih, Grace, Coccia, Marco A., Kohno, Tadahiko, Tafuri-Bladt, Anna, Campbell, Pauline, Chiu, Laura, Dai, Tianang, Elliott, Gary S., Hui, Ariela, McCabe, Susan M., Shaklee, Christine L., Senaldi, Giorgio
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
T cell antigen receptors, T cells

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