S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
Article Abstract:
A demonstration, in brains manifesting sporadic Parkinson's or Alzheimer's disease, that protein-disulphide isomerase (PDI) is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function is presented. NO-induced S-nitrosylation of PDI inhibits its enzymatic activity, leads to the accumulation of polyubiquitinated proteins, and activates the unfolded protein response.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
Article Abstract:
A demonstration, in brains manifesting sporadic Parkinson's or Alzheimer's disease, that protein-disulphide isomerase (PDI) is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function is presented. NO-induced S-nitrosylation of PDI inhibits its enzymatic activity, leads to the accumulation of polyubiquitinated proteins, and activates the unfolded protein response.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Turning down, but not off: neuroprotection requires a paradigm shift in drug development
Article Abstract:
The problem of increasing number of neurodegenerative diseases and their socioeconomic effect which has lead economist to the conclusion that by 2050, much of the economy will be spent covering the cost of these diseases, is examined. The various drugs and test developed to curb this predicament are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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