SUMOylation regulates kainate-receptor-mediated synaptic transmission

Article Abstract:

The small ubiquitin-like modifier protein (SUMO) has regulated the transcriptional activity across the nuclear membrane and multiple SUMOylation targets are found at synapses in rat hippocampal neurons. The electrophysiological recordings in hippocampal slices have shown that SUMOylation decreases kainate-receptor-mediated excitatory postsynaptic currents and increased by deSUMOylation.

Methyl aspartate, N-methyl-D-aspartate, Report

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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

Article Abstract:

CHIP enhances Hsp70 induction during acute stress and mediates its turnover during the stress recovery process. CHIP preferentially ubiquitinates chaperone-bound substrates, whereas degradation of Hsp70 by CHIP-dependent targeting to the ubiquitin-proteasome system occurs when misfolded substrates are depleted.

Acute stress disorder, Substrates (Biochemistry)

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Hair cell synaptic ribbons are essential for synchronous auditory signalling

Article Abstract:

A study shows that anchoring of cochlear inner hair cell ribbons is impaired in mouse mutants for the presynaptic scaffolding protein Bassoon. The study concludes that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing.

Hearing loss

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