Structural basis for AMP binding to mammalian AMP-activated protein kinase

Article Abstract:

The crystal structure of the regulatory fragment of mammalian AMP-activated protein kinase (AMPK) in complexes with AMP and ATP is described. The structure has provided a mechanism for propagating AMP/ATP signaling whereby a phosphorylated residue from the [alpha] and/or [beta] subunits are bound to the [gamma] subunit in the presence of AMP but not when ATP is bound.

Mutation (Biology), Mutation, Protein kinases, Adenosine triphosphate, ATP, Adenylic acid, Adenosine monophosphate

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The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design

Article Abstract:

X-ray crystallography is used to show that the two groups of H5N1 avian influenza virus are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding and the analysis has indicated that it might be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.

Usage, Drug therapy, X-ray crystallography, Avian influenza

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High-resolution structure of a retroviral capsid hexameric amino-terminal domain

Article Abstract:

Retroviruses are the aetiological agents of a range of human diseases including AIDS and T-cell leukaemias. They follow complex life cycles, which are still only partly understood at the molecular level. Observations are providing new insights into retroviral uncoating and how cellular restriction factors may interfere with viral replication.

Retroviruses, Virus replication

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