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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

Article Abstract:

The single-stranded-DNA-binding domain of human replication protein A (RPA) bound to DNA is composed of two structurally homologous subdomains. The single-stranded DNA (SSDNA) is found in a channel that runs across both subdomains. The structure of each RPA70 subdomain is similar to the structure of bacteriophage single-stranded-DNA-binding proteins. RPA70 is the largest subunit that binds to SSDNA and mediates interactions with cellular and viral proteins.

Author: Pfuetzner, Richard A., Bochkarev, Alexey, Frappier, Lori, Edwards, Aled M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Proteins, DNA binding proteins, Protein structure

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Crystal structure of the CorA M[g.sup.2+] transporter

Article Abstract:

The CorA family of magnesium transporters is the primary M[g.sup.2+] uptake system of most prokaryotes and a functional homologue of the eukaryotic mitochondrial magnesium transporter. The crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 Angstrom and 1.85 Angstrom resolution, respectively is determined.

Author: Bochkarev, Alexey, Edwards, Aled M., Maguire, Michael E., Joachimiak, Andrzej, Koth, Christopher M., Lunin, Vladimir V., Dobrovetsky, Elena, Khutoreskaya, Galina, Rongguang Zhang, Doyle, Declan A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Primary nonferrous metals, not elsewhere classified, Electric properties, Prokaryotes, Magnesium, Magnesium (Metal)

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Article Abstract:

The structures of human insulin-degrading enzyme (IDE) in complex with four substrates (insulin B chain, amyloid-beta peptide (1-40), amylin and glucagon) are reported. The molecular basis for substrate recognition and allosteric regulation of IDE might help in designing IDE-based therapies to control cerebral amyloid-beta and blood sugar concentrations.

Author: Joachimiak, Andrzej, Yuequan Shen, Rosner, Marsha Rich, Wei-Jen Tang
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Illinois, Protein synthesis, Protein biosynthesis, Crystallization, Structure, Allosteric enzymes

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Subjects list: Analysis, Research
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