Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

Article Abstract:

Cyclin-dependent kinases four and six (Cdk4/6), controlling the G1 stage of cell cycle, and their p16INK4a tumour suppressor inhibitor have an important role in cell proliferation and tumorigenesis. INK4 inhibitors bind adjacent to the ATP-binding site of the catalytic cleft and prevent cycling binding indirectly by making structural changes propagating to the cyclin-binding sites. This explains how they inhibit preassembled Cdk4/6-cyclin D complexes.

Protein kinases, Tumor suppressor genes

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Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

Article Abstract:

The three dimensional structures of the catalytic domain of human Phosphodiesterases (PDEs) complexed with three drug molecules are presented. These structures will provide opportunities to design potent and selective PDE inhibitors with improved pharmacological profiles.

United States, Phosphodiesterases, Anti-impotence agents

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Is TALL-1 a trimer or a virus-like cluster?

Article Abstract:

The active TALL-1 is trimeric under normal physiological conditions and biologically active as per the B-cell proliferation. According to the findings, the introduction of an amino-terminal histidine tag affects the oligomerization state of TALL-1.

Influence, B cells, Protein research, Histidine, Oligomers

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