Structural basis for the function and inhibition of an influenza virus proton channel
Article Abstract:
The crystal structure of the transmembrane-spanning region of the homotetrameric M2 protein isolated from influenza A virus, in presence and absence of the channel-blocking drug amantadine is described. The findings could be used to design new inhibitors that target amantadine-resistant mutants of M2 for treatment of endemics outbreaks and future pandemics caused by this pathogen.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA
Article Abstract:
A 3.2 crystal structure of the influenza viral nucleoprotein that forms the protein scaffold of the helical genomic ribonucleoprotein complexes and has a critical role in viral RNA replication is reported, The nucleoprotein's overall shape resembles a crescent with a head and a body domain, with a protein fold different compared with that of the rhabdovirus nucleoprotein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Proteins hunt and gather
Article Abstract:
The article discusses how proteins in living organisms bind to its own folded protein partner to form a final complex structure.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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