Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Article Abstract:

The crystal structure of C3b in complex with CRIg is presented and, using CRIg mutants, evidence that evidence that CRIg acts as an inhibitor of the alternative pathway of complement is provided. It is shown that CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases and the structure has provided insights into the complex macromolecular structural rearrangements that occur during complement activation and inhibition.

Macromolecules, Complement fixation

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Structure of the insulin receptor ectodomain reveals a folded-over conformation

Article Abstract:

The crystal structure at 38 angstrom resolution of the IR-An ectodomain dimer, complicated with four Fabs from the monoclonal antibodies 83-7 and 83-14, grown in the presence of a fragment of an insulin mimetic peptide is described. The structure reveals the domain arrangement in the disulphide-linked ectodomain dimer, showing that the insulin receptor adopts a folded-over conformation that places ligand-binding regions in juxtaposition.

Ligand binding (Biochemistry), Insulin, Insulin receptors

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Going to ground

Article Abstract:

The task of finding 'ground-state' configuration of particles and proving that they minimize the energy of the system is difficult. But the problem seems to be solved as Andras Suto demonstrates with a strikingly powerful mathematical argument that, in certain cases, the ground-state configuration sought when a material freezes into a regular crystal structure is a periodic one.

Electron configuration

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