Structure of a unique binuclear manganese cluster in arginase

Article Abstract:

An investigation of the 2.1 angstrom-resolution crystal structure of trimeric rat liver arginase reveals the location of this unique metal cluster at the bottom of an active-site cleft which is 15 angstrom deep. A study of the structure suggests that a metaactivated solvent molecule which symmetrically links the two Mn(super 2+) ions achieves arginine hydrolysis. Arginine hydrolysis in humans allows the disposal of nitrogenous waste from protein catabolism and is catalyzed by the liver arginase enzyme.

Research, Urea, Hydrolysis, Arginase

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Cluster-weighted modelling for time-series analysis

Article Abstract:

Many new methods to model signals produced by complex systems have been introduced over the past ten years, however they can produce misleading or incorrect results. It is shown that nonlinear, non-stationary, non-gaussian and discontinuous signals can be described by expanding the probabilistic dependence of the future on the past, around local models. The method gives forecasts of errors in prediction and model estimation, providing a transparent architecture and straightforward implementations.

Models, Usage, Signals and signaling, Signaling, Nonlinear theories

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Molecular growth from a Mo(super176) to a Mo(super248) cluster

Article Abstract:

Many compounds, clusters and solid-state structures can be formed in polyoxometalate chemistry, by linking well-defined metal-oxygen building blocks. Ring-shaped mixed-valence polyoxomolybdates type Mo(sub154) and Mo(sub176) have been reported, representing a nd type of giant clusters having nanometre-sized cavities. The formation of related clusters of Mo(sub248) formed by adding further units to the inner surface of Mo(sub176) are described.

Observations, Chemical bonds, Molybdenum compounds

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