The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C.elegans

Article Abstract:

Insulin signalling in mammals controls glucose transport and the expression and activity of several metabolic enzymes. In the Caenorhabditis elegans nematode, a related pathway controls metabolism, development and longevity. The main role of DAF-2, a homologue of the mammalian insulin receptor, and AGE-1, a homologue of the catalytic subunit of phosphatidylinositol 3-OH kinase, signalling is to antagonize DAF-16. It is shown that null mutations in daf-16 suppress the effects of daf-2 or age-1 mutations.

Observations, Caenorhabditis elegans, Insulin

---

Casein kinase I transduces Wnt signals

Article Abstract:

It has been possible to identify gain-of-function, loss-of-function and biochemical evidence consistent with the view that the serine kinase casein kinase I (CKI) transduces Wnt signals. It is suggested that CKI is a conserved element of the Wnt signalling cascade and that CKI may function between dishevelled and GSK-3. It is possible that CKI is the kinase responsible for dishevelled phosphorylation rising in response to Wnt signalling, as it binds to and boosts the phosphorylation of dishevelled.

Cellular signal transduction

---

A molecular growth industry

Article Abstract:

The hormone pathway in the pituitary gland that controls growth has been investigated at the molecular level by two groups of researchers. They have found the pituitary receptor for the hypothalamic factor that induces the secretion of somatotropin (growth factor). This factor also induces the proliferation of the cells that secrete somatotropin. Both groups have managed to clone a genuine growth-hormone-releasing factor receptor. These findings could lead to treatments for dwarfism and gigantism.

Somatotropin, Acromegaly, Somatotropin releasing hormone, Somatotropin-releasing hormone, Dwarfism, Pituitary, Pituitary dwarfism, Somatotropin receptors

Similar abstracts:

• Abstracts: The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucelus. Cyclins in initiation
• Abstracts: TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. An RNA-export mediator with an essential nuclear export signal
• Abstracts: Transcription factor GATA-3 is required for development of the T-cell lineage. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
• Abstracts: Transcription factor GATA-3 is required for development of the T-cell lineage. part 2 JNK is required for effector T-cell function but not for T-cell activation
• Abstracts: A belated agreement that requires faster progress. Molecular biology skills in demand in Europe. Bright prospects for British biotech

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.