The beta-2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

Article Abstract:

It has been possible to identify a direct agonist-promoted connection between the beta-2-adrenergic receptor and the Na+/H+ exchanger regulatory factor (NHERF), a protein that controls the activity of the Na+/H+ exchanger type 3. The binding of NHERF to the beta-2-receptor tail was found to prevent NHERF from regulating NHE3, either by making the NHERF/NHE3 interaction impossible or by changing the conformation of NHERF so that it cannot inhibit NHE3.

Beta adrenoceptors, Adrenergic beta receptors

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Switching of the coupling of the b2-adrenergic receptor to different G proteins by protein kinase A

Article Abstract:

Research demonstrates that beta-gamma subunits of pertussis-toxin-sensitive G proteins, through the beta2-adrenergic receptor, stimulate mitogen-activated protein kinase in HEK293 cells via a reaction with the G protein Ras and non-receptor tyrosine kinase c-Src. The decoupling reaction which causes heterologous desensitization at the beta2-adrenergic receptor is also responsible for G(sub s) receptor coupling.

Epinephrine, Adrenergic receptors, Pertussis toxin, Adrenergic mechanisms

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upsilon-Opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependance

Article Abstract:

Research into the development of opiate tolerance assesses the contribution of desensitization of the upsilon-opoid receptor to morphine tolerance but not dependence.

Physiological aspects, Endorphins, Morphine

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