The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus

Article Abstract:

The histone chaperone protein HIRA is essential for chromatin nucleosome assembly during sperm nucleus decondensation, and HIRA is critical for a nucleosome assembly pathway, independent of DNA synthesis that specially involves the H3.3 histone variant. The exclusive marking of paternal chromosomes with H3.3 represents a primary epigenetic distinction between parental genomes in the zygote, and underlines the consequence of the function of HIRA at fertilization.

Histones, DNA synthesis

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Assembly of the inner rod determines needle length in the type III secretion injectisome

Article Abstract:

The completion of the assembly of the inner rod is found to determine the size of the needle substructure in the type III secretion injectisome found in Salmonella typhimurium. The results have shown that the assembly of the inner rod, which is regulated by the InvJ protein, triggers conformational changes on the cytoplasmic side of the injectisome, reprogramming the secretion apparatus to stop secretion of the needle protein.

Connecticut, Health aspects, Causes of, Food poisoning, Salmonella typhimurium

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Chaperone release and unfolding of substrates in type III secretion

Article Abstract:

A demonstration that InvC, an ATPase associated with a Salmonella enterica type III secretion system, has a critical function in substrate recognition is presented. Results reveal a similarity between the mechanisms of substrate recognition by type III protein secretion systems and AAA+ ATPase disassembly machines.

Secretion, Salmonella enteritidis

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