The protein MAP-1B links GABAc receptors to the cytoskeleton at retinal synapses

Article Abstract:

GABAA and GABAC receptors are the main sites of rapid synaptic inhibition in the central nervous system. GABAC receptors consist of rho-subunits and are expressed solely in the retina of adult vertebrates. It is shown that there is interaction between the microtubule-associated protein 1B (MAP-1B) and the GABAC rho1 subunit, but not with GABAA receptor subunits. GABAC receptors and MAP-1B co-localize, and the co-expression of MAP-1B and the rho1 subunit in COS cells leads to the redistribution of the rho1 subunit.

Retina, Synapses

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A cluster of three GABAa receptor subunit genes is deleted in a neurological mutant of the mouse p locus

Article Abstract:

Research has revealed the location of the genes responsible for the mouse pink-eyed cleft-palate mutation. The genes affecting this disorder encode the gamma-aminobutyric acid type A (GABAa) receptor subunits sigma5, beta3 and gamma3 and are disrupted by a deletion in these mutant mice. The sigma5 and gamma3 genes are located between the p and beta3 genes on chromosome 7. This deletion provides an in vivo model for studying GABAa.

Genetic aspects, Mice, mutant strains, Mutant mice, Genetic disorders

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GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

Article Abstract:

Type-A receptors for GABA mediate inhibitory neurotransmission. Each subunit has ligand-binding sites and a large intracellular loop which could be a target for protein kinases. A new cellular protein, GABAA-receptor-associated protein (GABARAP) has been identified, that interacts the gamma2 subunit of GABAA receptors, and binds to GABAA receptors in vitro and in vivo.

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