The same prion strain causes vCJD and BSE
Article Abstract:
It seems very likely that the human prion disease new variant Creutzfeldt-Jakob disease (vCJD) is the human counterpart of bovine spongiform encephalopathy (BSE). It was established that mice expressing valine 129 human PrP produce a distinct molecular strain type when exposed to vCJD. This indicates that BSE transmitted to humans of this genotype may produce a similar strain. 129VV mice were found to be much less susceptible to BSE than to typical CJD, but 129MM human PrP mice could be a lot more susceptible.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Biochemical typing of scrapie strains
Article Abstract:
Glycoform ratio analysis of mouse-passaged virus scrapie strains is an appropriate tool to distinguish between transmissible spongiform encephalopathy strains. However, the virus changes form after one or more passages through its host, rendering it difficult to identify without further research to establish its type.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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HLA-DQ7 antigen and resistance to variant CJD
Article Abstract:
It is shown that the frequency of the human leukocyte antigen class-II type DQ7 is reduced in patients with variant Creutzfeldt-Jakob disease, although it is not reduced in patients with classical CJD, suggesting a protective genetic factor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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