Tolerance by exhaustion

Article Abstract:

Viruses may escape protective immune response by overwhelming the immune system with their sheer numbers. Under such a situation, the immune system puts up a brief and intense struggle, which eventually leads to exhaustion, deletion of T-lymphocytes and tolerance to the virus. Maintaining the tolerant host alive is advantageous to the virus because the host then becomes a carrier for the rest of its life. This phenomenon has been observed in many animal models, and also in humans exposed to high virus doses.

Abnormalities, Viruses, Immune system, Immunological tolerance, Immunologic tolerance

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Crucial role of the pre-T-cell receptor alpha gene in development of alpha-beta but not gamma-delta T cells

Article Abstract:

The pre-T cell receptor is necessary for the development of the early thymocytes. The formation of alpha-beta T cells is inhibited in mice lacking the pre-T-cell-receptor alpha gene but the formation of gamma-delta T cells is unaffected. The alpha gene encodes a transmembrane protein which is expressed only in immature T cells.

Gene expression, Cell differentiation, T cells

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Different initiation of pre-TCR and gamma-delta-TCR signalling

Article Abstract:

Research examining the initiation of signalling from the gamma-delta-TCR (T-cell receptor) and pre-TCR using confocal microscopy and biochemistry is presented. There are found to be clear differences between each type.

Biochemistry, Developmental biology

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