Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Article Abstract:

An analysis of several protein-tyrosine kinases suggests that the specificity of these kinases arises due to the ability of the SH2 domains to identify phosphotyrosine. The receptor tyrosine kinases phosphorylate group III SH2 domain-recognized peptides, while those recognized by group I SH2 domains are phosphorylated by cytosolic tyrosine kinases. Any mutation on the tyrosine kinases results in a variation in peptide substrate specificity, corroborating the need for catalytic specificity for selective signaling in human diseases.

Enzymes, Protein tyrosine kinase, Protein-tyrosine kinase, Enzyme structure-activity relationships

---

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Article Abstract:

The three-dimensional structure of Cbl-N, the evolutionarily conserved amino-terminal region of the adaptor protein Cbl, has been determined in order to improve understanding of its diverse recognition and regulatory functions. It has been established that Cbl-N is made up of an N-terminal four-helix bundle, a calcium-binding domain with the EF-hand fold and an SH2 domain. It appears that these three domains together form an integrated structure that is vital for phosphoprotein recognition.

Analysis, Protein binding, Protein research

---

Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface

Article Abstract:

The crystal structure of the intercellular adhesion molecule ICAM-2's extracellular region is presented. In this structure, the aspartic acid residue and fibronectin lie in protruding loops while glutamic acid residue, which is surrounded by a flat recognition surface, lies on a beta-strand. This may indicate variances in the structure of recognition sites between integrins that lack or contain I domains.

Cell adhesion molecules, Proteins, Protein structure

Similar abstracts:

• Abstracts: Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
• Abstracts: A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Patterns of somatic mutation in human cancer genomes
• Abstracts: Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor. DNA topoisomerase II alpha is required for RNA polymerase II transcription on chromatin templates
• Abstracts: Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
• Abstracts: Early aqueous activity on primitive meteorite parent bodies. Survival of isotopically heterogeneous graphite in a differentiated meteorite

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.