Towards a proteome-scale map of the human protein-protein interaction network

Article Abstract:

An initial version of a proteome-scale map of human binary protein-protein interactions is described and the pairwise interactions among the products are tested using a stringent, high-throughput yeast two-hybrid system. The data set, called CCSB-HI1, increases by approximately 70 percent of the set of available binary interactions within the tested space and shows more than 300 new connections to over 100 disease-associated proteins.

United States, Protein research, Proteomics

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Transcriptional coactivator PGC-1[alpha] integrates the mammalian clock and energy metabolism

Article Abstract:

Ppargcla (PGC-1[alpha), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and skeletal muscle of mice and it also stimulates the expression of clock genes through coactivation of the ROR family of orphan nuclear receptors. PGC-1[alpha] is identified as a main component of the circadian oscillator that has integrated the mammalian clock and energy metabolism.

Physiological aspects, Energy metabolism, Genetic transcription, Transcription (Genetics), Bioenergetics, Mammals

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Bac-to-Bac images of the brain

Article Abstract:

Gene Expression Nervous System Atlas (GENSAT) Bacterial Artificial Chromosomes (BAC) transgenic project is aimed to map genes for neuronal development. This functional- based map of the brain will construct a demographic atlas of the brain, and identify patterns of gene expression in individual neurons.

Genetic aspects, Brain research, Neurons

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