Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

Article Abstract:

The mutated protein Stargazin is found to regulate synaptic targeting of AMPA receptors.

Proteins

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Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Article Abstract:

A demonstration that the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor interacting protein, stargazin, not only mediates AMPA receptor trafficking but also shapes synaptic responses by slowing channel deactivation and desensitization is presented. The cytoplasmic tail of stargazin determines receptor trafficking, whereas the ectodomain controls channel properties.

United States, Science & research, All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Propionic Acid, Receptor antibodies, Cytoplasm

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Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors

Article Abstract:

The concentration of glutamate increases and its clearance is delayed when there is enhancement of transmitter release at hippocampal mossy fiber synapses, thus allowing glutamate to spread away from the synapse and activate presynaptic inhibitory metabotropic glutamate receptors (mGluRs). However, there is no activation of these receptors at normal levels of glutamate release during low-frequency activity. Therefore, this use-dependent activation underscores a negative feedback mechanism for controlling the strength of synaptic transmission.

Glutamate, Neurotransmitter receptors

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