Will biomedicine outgrow support?

Article Abstract:

Biomedical science has seen dramatic growth in developed countries over the past 50 years, and support by governments has also grown. However scientists continue to suffer from a funding crisis, making it harder to obtain support. A survey has been undertaken estimating the increase in the numbers of scientists engaged in the field since the Second World War, and comparing the rise to the increase in government spending in the US, Britain and Germany. Government spending on biomedical research increased steeply between 1950-1970 in the US, but less so in the UK and Germany. After 1970 it has remained constant in the UK and Germany, but is still growing in the US.

Surveys, Medical sciences

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Taking the pressure off

Article Abstract:

The in vivo and in vitro study of the interaction of NO with thiol groups in proteins and peptides using chemiluminescence methods shows the presence of excess glutathione in human lung alveoli. NO reacts with glutathione to form S-nitroso (SNO)-glutathione. SNO-glutathione is more stable than NO, having a half-life of several hours rather than seconds. SNO-glutathione reduces NO toxicity and relaxes the smooth vascular epithelium in human airways. SNO-cysteine is an even more potent vasorelaxant due to its rapid decomposition.

Physiological aspects, Muscles, Nitric oxide, Muscle tone, Glutathione, Smooth muscle

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Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

Article Abstract:

Research describing the expansion of repeat sequences of glutamine residues and their relationship with the onset of neurodegenerative diseases is presented. In particular the process of aggregate nucleation is investigated.

Nervous system, Huntington's chorea, Huntington's disease, Nerve degeneration, Glutamine

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